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  Create New Wish List. sidebar. Benzac AC 5% Gel Tube 15g Related Products. Differin 0.1% Anti Acne Gel 15g. Quick view BENZAC 5% Gel BENZAC. 10%. Gel. Cutaneous use. 10 % (w/w). Italy. GALDERMA ITALIA S.P.A which contains adapalene 0.1% and benzoyl peroxide 2.5% EPIDUO Gel safely and effectively. See full prescribing information for EPIDUO Gel. EPIDUO® (adapalene and benzoyl peroxide) Gel 0.1% / 2.5%    

 

Acne: Prescription Topical Treatment Options - Health Tools - Medbroadcast.



   

Order Acne Treatment Online

Medicines at a glance

How the service works

Just 4 simple steps
Complete consultation

Complete a free online medical consultation. Your answers provide our doctors with the information they need to safely recommend the right treatment for you.

Choose treatment

A doctor will review your consultation and, if it is safe to do so, approve you for treatment. Our doctors will suggest suitable treatment options, including dosage and treatment duration. Select your medicine and complete your order using our secure payment system.

Prescription issued

All prescriptions are sent electronically to our UK based partner pharmacy, ready for dispatch. Our partner pharmacy is regulated by the General Pharmaceutical Council and only dispenses genuine branded medicines licensed for use in the UK.

Medicine delivered

Medicines require a signature upon delivery. Most orders are dispensed and dispatched for delivery the next working day. All orders are sent using discrete packaging with no mention of Anytime Doctor or the parcel content. Upgrade to same day delivery for orders within the M25.

All of our prices are fully inclusive. When buying your treatment online our price includes the cost of the consultation, the issuing of a private prescription, dispensing of the medicine itself, free delivery and doctor after-care. There are no hidden extras.

We aim to offer you similar pattern of healthcare as if you were to visit your normal GP for a face to face consultation. We believe it is important that you complete a medical consultation to ensure that the treatment option you are requesting is appropriate for your needs. Our GMC registered doctors are also able to suggest treatment options for you if you prefer. Once a doctor has approved you for treatment all prices are clearly displayed. Your medical consultation and registration is free and you are under no obligation to purchase any treatment after your consultation.

In order to manage some conditions online, we are required to inform your GP about the medicine you have been prescribed. This will be clearly highlighted during your consultation. We will not contact or share this information with your GP without your consent. You are required to provide consent each time you order, so you remain in full control of when we contact your GP on your behalf.

Your Anytime Doctor medical record is confidential and securely stored on our UK data servers. We will never share your details unless you expressly ask us to do so.

Which acne treatment is best for me?

If over the counter treatments have not helped your acne, you may be suitable to try prescription only topical treatments. There are many to choose from and many have different active ingredients. You may wish to consider trying topical treatments one by one in the following order (not at the same time), moving up one level if the previous treatment has been unsuccessful after 8 weeks of use.

  • 1Zineryt (topical antibiotic) OR
    Differin (topical retinoid) OR
    Skinoren (azelaic acid) which works in a similar way to the peeling agent benzoyl peroxide
  • 2Duac Once Daily (topical antibiotic and peeling agent benzoyl peroxide) OR
    Epiduo (topical retinoid and peeling agent benzoyl peroxide)
  • 3Antibiotic tablets for acne (not available through Anytime Doctor)

Our doctors will advise if you are unsure which treatment you need.

How effective is topical acne treatment?

Results should be noticeable within four to eight weeks of starting treatment. Topical treatments need to be used regularly for several months. The length of treatment will vary from person to person, depending on how bad the acne is at the beginning of treatment.

Regulatory Information

Last reviewed & updated  17/11/2019   Authored  24/01/2010

Acne: Prescription Topical Treatment Options

Treatment

Single-ingredient products

Aczone™ (dapsone)

  • It is not known exactly how dapsone works for acne.

Aklief® (trifarotene)

  • Trifarotene unplugs blocked hair follicles and prevents new plugs from forming.

Benzac W*, Persaclear*, others (benzoyl peroxide)

  • Benzoyl peroxide kills acne bacteria, but it is not an antibiotic. It also acts as a peeling agent.

Dalacin® T, others (clindamycin)

  • Clindamycin is an antibiotic that stops acne bacteria growth.

Differin®, Differin® XP™ (adapalene)

  • Adapalene unplugs blocked pores and prevents new plugs from forming.

Retin-A®, Retin-A Micro® (tretinoin)

  • Tretinoin alters the rate of growth and shedding of skin cells to unclog pores and blocked oil glands and prevent new plugs from forming.

Tazorac® (tazarotene)

  • Tazarotene alters the rate of growth and shedding of skin cells to unclog pores and blocked oil glands and prevent new plugs from forming. It also reduces inflammation caused by acne.

Benzaclin®, Clindoxyl® (clindamycin and benzoyl peroxide)

  • Clindamycin is an antibiotic that stops acne bacteria growth.
  • Benzoyl peroxide kills acne bacteria, but it is not an antibiotic. It also acts as a peeling agent.

Benzamycin® (erythromycin and benzoyl peroxide)

  • Erythromycin is an antibiotic that stops acne bacteria growth.
  • Benzoyl peroxide kills acne bacteria, but it is not an antibiotic. It also acts as a peeling agent.

Biacna™ (clindamycin and tretinoin)

  • Clindamycin is an antibiotic that stops acne bacteria growth.
  • Tretinoin alters the rate of growth and shedding of skin cells to unclog pores and blocked oil glands and prevent new plugs from forming.

TactuPump®, TactuPump® FORTE (adapalene and benzoyl peroxide)

  • Adapalene unplugs blocked pores and prevents new plugs from forming. It also reduces inflammation caused by acne.
  • Benzoyl peroxide kills acne bacteria, but it is not an antibiotic. It also acts as a peeling agent.

Products & Usage

Single-ingredient products

Aczone™ (dapsone)

  • Aczone™ 5% (authorized in 2011) is used to treat acne on the face, chest, back, and shoulders.
  • Apply 2 times daily, or as directed by your doctor.

Aklief® (trifarotene)

  • Aklief® 50 mcg/g (0.005% w/w) cream (authorized in 2019) is used to treat acne on the face and trunk (upper, middle and lower back, shoulders and chest).
  • Apply once daily, in the evening.

Benzac W*, Persaclear*, others (benzoyl peroxide)

  • Benzac W* wash gel 10% (authorized in 1991), Persaclear* 10% w/w cream (authorized in 2011) and others are used for acne.
  • Apply as directed on the product label or by your doctor.

Dalacin® T, others (clindamycin)

  • Dalacin® T 1% (authorized in 1991) and others are used to treat acne.
  • Apply 2 times daily.

Differin®, Differin® XP™ (adapalene)

  • Differin® XP™ 0.3% (authorized in 2007) and Differin® 0.1% (authorized in 1996) are used to treat acne.
  • Apply once daily, at bedtime.

Retin-A®, Retin-A Micro® (tretinoin)

  • Vitamin A acid 0.01%, 0.025%, 0.05% (authorized in 1989), Stieva-A® 0.01%, 0.025%, 0.05% (authorized in 1981), Retin-A Micro® 0.04%, 0.1% (authorized in 1991), and Retin-A® 0.01%, 0.025%, 0.05%, 0.1% (authorized in 2001) are used to treat acne.
  • Apply once daily, at bedtime.

Tazorac® (tazarotene)

  • Tazorac® 0.05% and 0.1% (authorized in 1997) are used to treat acne.
  • Apply once daily, before bed.

Benzaclin®, Clindoxyl® (clindamycin and benzoyl peroxide)

  • Clindoxyl® ADV 1%/5% (authorized in 2013) and Clindoxyl® 1%/3% (authorized in 2001) are used for moderate acne. Apply once daily.
  • Benzaclin® 1%/5% (authorized in 2004) is used for moderate acne. Apply 2 times daily.

Benzamycin® (erythromycin and benzoyl peroxide)

  • Benzamycin® 3%/5% (authorized in 1996) is used for moderate acne.
  • Apply 2 times daily, or as directed by your doctor.

Biacna™ (clindamycin and tretinoin)

  • Biacna™ 1.2%/0.025% (authorized in 2011) is used for acne.
  • Apply once daily, at bedtime.

TactuPump®, TactuPump® FORTE (adapalene and benzoyl peroxide)

  • TactuPump® FORTE 0.3%/2.5% (authorized in 2016) is used for moderate-to-severe acne on your face, chest, and back. It can be considered for people who are at risk of acne scarring.
  • TactuPump® 0.1%/2.5% (authorized in 2011) is used for mild-to-moderate acne on your face, chest, and back. It can be considered for people who are at risk of acne scarring.
  • Apply once daily at night, before you go to bed.

*This is not a complete list of all possible side effects. For any unexpected effects while taking any of these treatments, contact your doctor or pharmacist.

Common side effects*

Single-ingredient products

Aczone™ (dapsone)

  • Skin dryness, redness, oiliness, and peeling.

Aklief® (trifarotene)

  • Skin redness, dryness, itching, peeling, burning, stinging, and pigment loss of the skin.

Benzac W*, Persaclear*, others (benzoyl peroxide)

  • Skin redness, irritation, stinging, and burning.

Dalacin® T, others (clindamycin)

  • Skin redness, rash, dryness, itching, burning, or peeling when you first start to use it; headache, diarrhea, nausea.

Differin®, Differin® XP™ (adapalene)

  • Skin redness, dryness, itching, burning, or peeling when you first start to use it (2 to 4 weeks).

Retin-A®, Retin-A Micro® (tretinoin)

  • Skin peeling, burning, irritation, itching, dryness, stinging, flaking, and redness in the first few weeks.

Tazorac® (tazarotene)

  • Burning, peeling, redness, dry and itchy skin; skin irritation and stinging.

Benzaclin®, Clindoxyl® (clindamycin and benzoyl peroxide)

  • Skin redness, dryness, itching, irritation, or peeling.

Benzamycin® (erythromycin and benzoyl peroxide)

  • Skin redness, dryness, itching, irritation, burning or peeling; inflammation of the face, eyes and nose, irritation of the eyes, skin discoloration, oiliness, tenderness of the skin, and edema.

Biacna™ (clindamycin and tretinoin)

  • Headache, sunburn, upper respiratory infection, temporary skin colour change (lighter or darker).

TactuPump®, TactuPump® FORTE (adapalene and benzoyl peroxide)

  • Skin redness, dryness, itching, burning, or peeling when you first start to use it (2 to 4 weeks).

*This is not a complete list of all possible side effects. For any unexpected effects while taking any of these treatments, contact your doctor or pharmacist.

TAKE-HOME MESSAGE

  • This split-face study in 20 patients with acne utilized clindamycin 1%–tretinoin 0.025% (CT) and benzoyl peroxide 2.5%–adapalene 0.1% (BA) gels for 21 days. There were significant increases in erythema, dryness/scaling, and burning/stinging with BA; although participants reported reduced acne with BA, the blinded evaluators found similar reduction in acne lesion counts with both treatments.  

  • While both CT and BA led to reduction in acne with 3 weeks of daily use, CT was better tolerated which may be important for patient satisfaction and compliance with acne treatment.

–  Caroline K. Crabtree, MD

Acne vulgaris is the most common dermatological disorder worldwide, causing significant physical and psychological morbidity. Topical combination therapy has shown superior efficacy compared to monotherapy, especially when combined with retinoids. Few studies have directly compared combined formulations. This evaluator-blinded pilot study compared the efficacy and tolerability of two marketed topical combination acne gels, clindamycin 1%-tretinoin 0.025% (CT) and benzoyl peroxide 2.5%-adapalene 0.1% (BA) in 20 patients with mild to moderate acne vulgaris. Gels were applied daily on opposite sides of the face for 21 days. The primary outcome was difference in transepidermal water loss (TEWL) at the end of treatment. Secondary endpoints were skin moisture content measurement, Investigators' Global Assessment, subject self-assessments (SSA) of burning/stinging, itching, erythema, and dryness/scaling, and Comparative Participant Satisfaction Questionnaire (CPSQ). Efficacy was assessed by inflammatory and non- inflammatory acne efflorescences counts. TEWL increased significantly for both CT and BA (+57.74%, P=0.002; +58.77%, P<0.001); skin moisture content significantly decreased only for BA (-16.47%, P=0.02). Only BA showed a significant increase in erythema and dryness/scaling (P=0.027 and P=0.014) and in SSA burning/stinging (P=0.04). Patient satisfaction evaluation also reflected the strong BA irritation. Although CT and BA both reduced acne lesions (P<0.001) and more patients preferred to continue with CT, subject perception of acne improvement was higher for BA. These findings suggest that CT and BA have similar efficacy in the treatment of mild to moderate papulopustular acne. However, CT was better tolerated than BA by both medical and subject evaluation. CT is an effective and tolerated treatment option.J Drugs Dermatol. 2021;20(3):295-301. doi:10.36849/JDD.2021.5641.



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